卡尔克. 约翰逊

Sarah Rempel and Herbert S. Rempel 教授essor of Neuroscience; On leave for the 2024-2025 academic year
  • Expertise

    Expertise

    Karl 约翰逊’s research is aimed at understanding how developing neurons find and make their appropriate synaptic connections in simple central nervous systems, 使用 Drosophila (the common fruit fly) as a model organism. His research focuses on identifying novel genes that are essential for two aspects of nervous system development—first, how neurons find their proper synaptic targets, and second, how neurons build synapses.

    He and his team of undergraduate researchers have begun to characterize how heparan sulfate proteoglycans (HSPGs) influence central nervous system development, and are foc使用 their current efforts on examining the roles of two HSPGs, syndecan and dallylike, in axon guidance and synapse formation.

    Research Interests

    约翰逊’s ongoing research is exploring the role a group of evolutionarily ancient molecules called heparin sulfate proteoglycans (HSPGs) play in central nervous system development in Drosophila. 

    Areas of Expertise

    • 生物学
    • Molecular 生物学
    • Developmental Neurobiology
    • Developmental 生物学
    • Axon Guidance
  • 工作

    工作

    与维. Arizanovska and J. 王. “Syndecan affects odor response as well as learning and memory in Drosophila melanogaster.”  American Journal of Undergraduate Research 15(1): 23-32, 2018.

    与米. Nguyen, J., Kwong, J. 常,V.G. Gillet, R.M. 李. “The Extracellular and Cytoplasmic domains of Syndecan cooperate postsynaptically to promote synapse growth at the Drosophilaneuromuscular junction.” 《皇冠体育》 11(3):e0151621, 2016.

    与E. Ozkan R.A. Carrillo, C.L. Eastman, R. Weiszmann, D. Waghray, K. 津恩,年代.E. Celniker, K.C. 加西亚. “An Extracellular Interactome of Immunoglobulin and LRR Proteins Reveals Receptor-Ligand Networks.” 细胞 154(1):228-239, 2013.

    和我. Vilinsky. “Electroretinograms in Drosophila: A robust and genetically accessible electrophysiological system for the undergraduate laboratory.”  Journal of Undergraduate Neuroscience 教育 11(1); A149-157, . 2012.

    与一个.D. 聪明,米.M. 当然,J. 罗森,年代. Selleck, D. Van Vactor. Heparan sulfate proteoglycan specificity during axon pathway formation in the Drosophila 胚胎. Developmental Neurobiology 71(7):608-618, 2011

    与一个.P. 赖特,.N. Fox, and K. 辛. "Systematic screening of Drosophila deficiency mutations for 胚胎nic phenotypes and orphan receptor ligands. 《皇冠体育》 5(8): e12288, 2010

    与E. Stryker ('07), "LAR, liprin-alpha and the regulation of active zone morphogenesis, " Journal of 细胞 Science, 120: 3723-3728, 2007

    与一个.P. Tenney, A. Duckworth, K. Parfitt, O. Marcu T. Heslip, J. L. 沼泽,J.G. Flanagan and D. Van Vactor, "The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert opposing effects on synapse growth," 神经元, 49(4): 517-531, 2006

    与维. Van Vactor and D.P. Wahl, "Heparan Sulfate Proteoglycans and the emergence of neuronal connectivity, " 咕咕叫. Op. Neurobiology, 16(1): 40-51, 2006

    与J.M. 罗森,B. Dimitroff, X. 通用电气、维. Van Vactor and S. B. Selleck, "The heparan sulfate proteoglycans Dallylike and Syndecan have distinct functions in axon guidance and visual system assembly in Drosophila," 咕咕叫ent 生物学,卷. 15:833-838, May 10, 2005

    与一个. Ghose用E. Epstein, J. Lincecum, M. B. O'Connor and D. Van Vactor, "Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent Slit during midline axon guidance," 咕咕叫ent 生物学, 14:499-504, 2004

  • 教育

    教育

    Ph.D.
    Cambridge University

    Master of Science
    University of California, San Diego

    Bachelor of Art
    Grinnell College

    教授essional Experience

    Postdoctoral Fellow

    Harvard Medical School

    Recent Courses Taught

    • Ind Std: 生物学
    • Intro 细胞 Chem & 细胞 Bio w/Lab
    • Lab, Intro 细胞 Chem & 细胞 Biol
    • Lab, Vertebrate Sensory Systems
    • Vertebrate Sensory Systems
  • 奖 & 荣誉

    奖 & 荣誉

    National Science Foundation, Research at Undergraduate Institutions. Division of Integrative Organismal Systems – Neural Systems Cluster. “Investigating the mechanisms of Syndecan function during nervous system development” $519,925 9/2009-8/2013

    National Institutes of Health, Academic Research Enhancement Award (AREA), three-year $216,556 grant for the project "Characterizing the function of Syndecan during CNS [central nervous system] development," 2008 (Declined)

    Wig Distinguished 教授essorship Award for Excellence in Teaching, 2008 & 2014

    National Science Foundation and Davidson College, $10,000 SOMAS grant, designed to support the research of new neuroscience faculty and their students at predominantly undergraduate institutions, 2008

    Helen Hay Whitney Postdoctoral Fellow, 2002-2005

    Cambridge Overseas Research 学生hip, 1997-2000

    Phi Beta Kappa, member, 1995-present